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Drowning in Data? Help Solve a Murder Mystery

[title]

Presenter: Sandra Porter
 

Preparation:  

Get Cn3D here:  http://www.ncbi.nlm.nih.gov/Structure/CN3D/cn3dinstall.shtml  and install it on your computer.

 

Schedule:  

Part I.  Get Cn3D going

A.  Download 1NAJ.cn3

  • Turn structures
  • Move structures without turning
  • Make structures bigger / smaller
  • Change rendering style
  • Change coloring style
  • Show and hide parts of a structure
  • Make color key

B.  Become familiar with Cytochrome Oxidase C

  • Look at chains - how many?

    • try different coloring styles - what do you see?
  • Look at active site

    • rendering style tubes, coloring style element
    • heme by a copper
  • Look at metal bonds

    • select copper at the active site
    • Select by distance - 5 angstroms
    • Show selected
    • change rendering style to Ball n Stick
    • Clear highlights

 

Part II.  Talk about Bio-ITEST bioinformatics curriculum for high school students

NSF ITEST grant to NWABR, Digital World Biology, EdLab Group, in collaboration with Shoreline Community College

Combines career education with bioinformatics & DNA barcoding & bioethics

 

Part III.  Solve the mystery

  • Divide into groups & get your structure - these are normal & mystery structures superimposed with VAST
  • Work with your group to solve the mystery
  • Present your results and theory to the class

 

Presenter affiliation: 
Bio-Link National Center
Presenter affiliation: 
Austin Community College
Presenter affiliation: 
Shoreline Community College

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